September 17, 2021

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Do you really need PGD?


Most people, who consider PGD / PGS within the fertility program, want it for gender selection. Indeed, this convenient option to choose the sex of your future baby is fabulous! No wonder it is growing in popularity. But gender selection is not the only reason to perform this procedure. What are the things you need to know about PGD? 5 PGD chromosomes or 24 PGD chromosomes, what’s the difference? There are risks, is it dangerous? Do you still need it if you don’t need gender selection? We will try to cover all these questions in our article.

What is PGD / PGS?

PGD ​​stands for “Preimplantation Genetic Diagnosis”. It is also often referred to as PGS – “Preimplantation Genetic Screening”. As the name suggests, this procedure is done before an embryo is transferred to the woman’s uterus to be tested for genetic diseases. During this procedure the specialist can also determine the sex of developing embryos, which is why it is often used for the purpose of sex selection. Gender selection can be used to prevent inheritance of genetic diseases and for family balance.

PGD ​​increases the success rate!

The first thing you need to know is that including PGD will improve the IVF success rates of your fertility program. The PGD test allows you to transfer only healthy biological material by checking the number and appearance of chromosomes, which helps prevent still pregnancies, miscarriages, fetal malformations, organ pathologies, Down syndrome, Patau syndrome etc. Transferring only healthy and strong embryos greatly increases the chances of a successful, normal and unproblematic gestational period, as demonstrated by fertility program statistics. So even if you don’t think about gender selection, you should really consider PGD as it will make your program more efficient. The PGD cost is quite high, but it is highly recommended because it reduces the number of attempts and shortens the road to success. Can’t be bad for a budget!

Is PGD Safe?

The short answer is yes! But we know that nothing is 100% safe in our world, so how safe is it? It is pretty sure that our Dr. Ruslan Sobolev recommends it to all intended parents!

But the opinion of a doctor cannot be enough, so it is good to know that according to the latest research on this topic, conducted by Dr. Sonja Desmyttere, involving data from hundreds of PGD procedures, it can be called completely safe!

That is why, taking into consideration all the advantages it offers, we are happy to recommend this option to all our customers.

5 PGD chromosomes or 24 PGD / PGS chromosomes?

Technically there are two methods of PGD:

The 5 chromosome PGD method performs the analysis of 5-10 even chromosomes. This is sufficient for gender selection and general genetic testing, but research shows that this method does not really improve results. In general, we don’t recommend this method, although it may be an option if you only need gender selection.

24 chromosome PGD analyzes all 24 chromosome pairs, which can greatly increase the chances of successful implantation and live birth of a healthy baby. According to studies, success rates can be twice as high with 24 PGD chromosomes. And of course, gender selection is also available.

Big brother and little sister

What is the best PGD method to choose?

The genetic test of the 24 chromosomes is much better, because it allows to discover the healthiest and potentially successful embryos for transfer. When our Intended Parents ask for the possibility of doing PGD within a surrogacy program in Ukraine, I always offer this test as a quick way to a successful pregnancy. The combination of a proven and healthy young egg donor, an experienced Ukrainian surrogate mother, reproductive treatment specialists, the best embryologists and such tests, which is performed in Ukraine or abroad, makes success from 1- 3 attempts.

Although I can fully understand future parents when they want to skip this test by giving all embryos a chance to go naturally to development. In some cases, even PGD is not a guarantee of outcome, there are many factors that play an important role in the success of a fertility program. If a couple does genetic screening of an embryo only to find out the sex of the future baby, 5 chromosome PGD screening is sufficient and this test is not as expensive as the 24 one.

There are many possibilities to increase the possibilities. PGD ​​is one of them

95% of our couples perform preimplantation diagnosis for the embryo and I see the obvious difference in success rates. With PGD it rises to 70% for the transfer of 2 tested embryos and the chances of getting twins are also higher. This advice can be an inspiration for IPs dreaming of twins. It is very common to transfer 2 embryos, a male and a female at the same time. PGD ​​for a planned twin pregnancy is more than recommended, because if one embryo is good and another will have development problems, then the risk of miscarriage is greater and twin pregnancy could be problematic.

I hope this information and my opinions on this topic will help you decide and think “do I need PGD test in IVF treatment?”. It is always a choice of the intended parents, but having such a powerful scientific technique at your disposal and not using it is a loss of chance.

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